2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

PDF 88.0 MB

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-135487
    Sibenadet 154189-40-9 98%
    Sibenadet (AR-C68397AA free base) is a dual dopamine D2/β2-adrenoceptor agonist with selective β2-adrenoceptor agonism. Sibenadet inhibits capsaicin-induced plasma protein extravasation in rat trachea. Sibenadet suppresses edema from sensory nerve fiber activation by activating β2-adrenoceptor. Sibenadet is promising for research of chronic obstructive pulmonary disease (COPD).
    Sibenadet
  • HY-135507
    NAS-181 205242-62-2 98%
    NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.
    NAS-181
  • HY-135543
    Levophencynonate 230313-75-4 98%
    Levophencynonate is a muscarinic receptor antagonist with anticholinergic activity. The biological activity of levophencynonate makes it a key target for the determination of its concentration in human plasma in medical research. Levophencynonate was analyzed by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and showed good specificity and linearity.
    Levophencynonate
  • HY-135563
    Oxoprolintane 35259-27-9 98%
    Oxoprolintane is a metabolite of the psychoactive compound Prolintane (HY-124217). Oxoprolintane has a role in regulating the central nervous system and may be a potential neuroprotective agent. Oxoprolintane is expected to be used in research on neurological diseases.
    Oxoprolintane
  • HY-135571
    VBIT-3 2088463-66-3 98%
    VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases.
    VBIT-3
  • HY-13557R
    Ascomycin (Standard) 104987-12-4
    Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].
    Ascomycin (Standard)
  • HY-135608
    BD-1008 138356-08-8 98.41%
    BD-1008 is a selective sigma 1 (σ1) receptor antagonist with a Ki of 2 nM. BD-1008 exhibits 4-fold selectivity over the sigma-2 receptor (Ki of 8 nM). BD-1008 can be used for the study of neurological diseases.
    BD-1008
  • HY-135628
    PD-85639 149838-21-1 98%
    PD-85639 is a voltage-gated sodium (Na+) channel blocker that has neuroprotective effects.
    PD-85639
  • HY-135649
    Tremorine 51-73-0
    Tremorine is an agent used to induce tremors in animals. Tremorine can be used to establish animal tremor models for the study of Parkinson's disease.
    Tremorine
  • HY-135749
    BN201 1361200-34-1 99.89%
    BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC50 of 6.3 μM) in vitro, and the myelination of new axons (EC50 of 16.6 μM). BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 has potently neuroprotective effects.
    BN201
  • HY-13575S
    Blonanserin-d8 98%
    Blonanserin-d8 is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic.
    Blonanserin-d8
  • HY-135880
    OMDM-3 616884-64-1 98%
    OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki of 16.6 μM.
    OMDM-3
  • HY-135881
    OMDM-5 616884-66-3 98%
    OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a Ki of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC50 of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (Ki=4.9 μM).
    OMDM-5
  • HY-135895
    Detomidine carboxylic acid 115664-39-6 98%
    Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic α2-adrenergic agonist. Detomidine also has cardiac and respiratory effects and an antidiuretic action.
    Detomidine carboxylic acid
  • HY-136092
    Androsta-1,4,6-triene-3,17-dione 633-35-2 98%
    Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory.
    Androsta-1,4,6-triene-3,17-dione
  • HY-136094
    SRT3657 1383551-17-4 98%
    SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
    SRT3657
  • HY-136189
    UK-59811 hydrochloride 2250025-89-7 98%
    UK-59811 hydrochloride, a Br-dihydropyridine derivative, is a potent bacterial homotetrameric model voltage-gated Ca2+ (CaV) channel CaVAb inhibitor with an IC50 of 194 nM.
    UK-59811 hydrochloride
  • HY-136232
    PSEM 308 hydrochloride 98%
    PSEM 308 hydrochloride is a pharmacologically selective actuator module (PSAM) agonist. PSEM 308 Activates PSAML141F-GlyR chimeric ion channels.
    PSEM 308 hydrochloride
  • HY-136238
    PM226 1949726-13-9 98%
    PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo.
    PM226
  • HY-136258
    nAChR agonist CMPI hydrochloride 2250025-94-4 98%
    nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)3(β2)2 nAChR to ACh (10 µM) with an EC50 of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.
    nAChR agonist CMPI hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity